You may have noticed that many prescription drug bottles have a warning that discourages the user from consuming grapefruit. As a general rule, any medication included in this legal notice may also interact negatively with Delta 8 THC. Of course, as with anything, the lower the dose of delta-8 you take while the drug is active in your body, the lower the risk of an interaction. When you start taking Delta-8, keep track of small details, such as how much Delta-8 you took, what time you took the prescription, what time you took your Delta-8 dose, how severe the effects were, or how long they lasted.
In this way, there is a lower chance that both substances will be present in the body at high levels at the same time. The most important step, of course, is to discuss Delta-8 with your doctor before combining any substances or changing your medication routine. Alcohol is also known to cause interactions with many medications, so if you're taking delta-8 with a doctor's prescription, avoid drinking until the next day. Delta-9-tetrahydrocannabinol (THC) and cannabidiol are pharmacologically active cannabinoids in marijuana that are metabolized in cytochrome P450 (CYP), 3A4; THC is also metabolized by CYP2C9, a liver enzyme.
One study found that studies on the inhibition and induction of THC, CBD and CBN of the main human isoforms of CYP-450 generally reflect a low risk of clinically significant drug interactions with most uses, but it also noted that human trials are lacking and that more information is needed. Now that delta-8-THC has become the center of attention, it is crucial to understand the risk of drug interactions between delta-8.Therefore, THC Delta 8, which acts as a CYP3A4 inhibitor, can cause certain drugs to accumulate in toxic concentrations in the body, which is the basis of the possible interaction. The FDA is also concerned that delta-8 THC products may expose consumers to much higher levels of the substance than those found naturally in raw hemp and cannabis extracts. As a hemp-derived cannabinoid, THC delta 8 is classified as a non-toxic substance, helping people feel comfortable incorporating it into their lifestyles.
At the end of the day, it's good to take a “prevention is better than cure” approach when it comes to mixing Delta 8 hemp products with prescription drugs. The Delta-8 is a degraded delta-9, has a lot in common with its older sister compound and is simply a softer version. If you are taking delta 8 hemp-derived products along with another CYP3A4 inhibitor, such as drinking grapefruit juice every morning, this will have a greater impact on how medications can be metabolized. Delta-8 is known to be much less potent, so it is believed to have an even lower potential for drug interactions.